New research indicates that people who come off popular GLP-1 drugs like semaglutide or tirzepatide may regain lost weight far faster than those who halt traditional lifestyle regimens.
Research printed in a prominent medical journal points out that while overweight people often shed about a fifth of their body weight while using the jabs, the mass is regained at an average rate of 0.8 kg per month after stopping.
"People using these treatments need to be cognizant of the danger of rapid rebound weight gain when the treatment concludes," cautioned expert Dr. Susan Jebb.
Such speed of regain means a return to starting mass in about 18 months.
Weighing Treatments
The research, which examined 37 of trials involving thousands of participants, compared the results of GLP-1 agonists with older methods.
Scientists emphasize that people who shed pounds through lifestyle changes alone usually see a slower weight regain—around 100 grams monthly—after stopping.
Understanding the Fast Rebound
Nutrition scientists believe the mode of action of the drugs is key to understanding the accelerated weight return.
These medications imitate a natural hormone called GLP-1, which controls feelings of fullness.
"Artificially providing GLP-1 levels far above than the body's typical production may cause the system to produce less of its own natural hormone, and could lessen responsiveness to its actions," explained Dr. Adam Collins, a dietetics specialist.
"Withdrawal of this medication means hunger is no longer kept in check, making overeating a significant risk."
A Chronic Disease?
Medical guidelines advise the injections for people with obesity-related medical conditions, accompanied by recommended lifestyle changes.
A number of clinicians argue that, given the likelihood of relapse, the treatment is often long-term.
This view is supported by drug manufacturers, who note that the findings "underscore the chronic nature of excess weight," akin to managing diseases like high blood pressure.
User Testimonies
Individuals who have stopped the medication explain a sudden return of cravings.
"It felt as if a switch activating and I was suddenly extremely hungry," said an individual.
This difficulty is compounded if individuals have not adopted permanent lifestyle or habit changes during therapy.
Significant Use
Figures suggest that millions of people in the UK have tried weight-loss jabs in the last 12 months, with demand remaining high.
- Use is greater among females than males.
- The 40s and 50s demographic shows the greatest level of interest.
- A large proportion obtain the drugs through private prescriptions rather than the NHS.
Ultimately, experts caution that while these medications are effective agents for weight loss, they are not a magic solution and long-term success likely depends on combined lifestyle changes.
